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JAMA Dermatology Clinicopathological Challenge
March 6, 2019

Multiple Lip Papules and Nodules in an Adult Man

Author Affiliations
  • 1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut
JAMA Dermatol. 2019;155(4):485-486. doi:10.1001/jamadermatol.2018.5240

A man in his 60s presented with an approximately 4-month medical history of lip enlargement with nodular growths. Skin examination was significant for multiple erythematous and flesh-colored papules and nodules symmetrically affecting the upper and lower lips with extension onto the vermilion border (Figure 1A). There were no intraoral lesions, and all other findings of his examination were within normal limits. The patient denied fevers, chills, weight loss, night sweats, cough, lymphadenopathy, abdominal pain, change in bowel habits, or other systemic symptoms. A biopsy was obtained of the vermilion lip (Figure 1B).

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