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April 10, 2019

Oral Tofacitinib Treatment of Erosive Pustular Dermatosis of the Scalp

Author Affiliations
  • 1Duke University School of Medicine, Durham, North Carolina
  • 2Department of Dermatology, Duke University Medical Center, Durham, North Carolina
JAMA Dermatol. 2019;155(6):752-754. doi:10.1001/jamadermatol.2019.0140

Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory dermatosis characterized by pustules, erosions, and crusting that can lead to cicatricial alopecia. Often, EPDS has a prolonged and undulating clinical course refractory to topical tacrolimus, isotretinoin, and photodynamic therapy.1,2 The cause of EPDS is poorly understood, but there are 2 common theories: autoimmune response and trauma.1 Previously, EPDS has been noted in patients with concurrent autoimmune conditions, including rheumatoid arthritis (RA), Hashimoto thyroiditis, autoimmune hepatitis, and Takayasu aortitis.3 We report a case in which oral tofacitinib was successful in the treatment of EPDS.

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