Is the use of ivermectin in patients infested with scabies associated with improved clinical and safety outcomes compared with permethrin?
Both ivermectin and permethrin treatment were associated with high clearance rates. There is low-certainty evidence that ivermectin was associated with slightly lower rates of complete clearance after 1 week compared with permethrin, 5%, cream (relative risk [RR], 0.65; 95% CI, 0.54-0.78). After 2 weeks, there was no difference in efficacy (RR, 0.91; 95% CI, 0.76-1.08; low-certainty evidence), or in the number of participants with adverse events (week 4: RR, 1.30; 95% CI, 0.35-4.83; low-certainty evidence).
Rosumeck S, Nast A, Dressler C. Evaluation of Ivermectin vs Permethrin for Treating Scabies—Summary of a Cochrane Review. JAMA Dermatol. Published online April 24, 2019155(6):730–732. doi:10.1001/jamadermatol.2019.0279
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