To the Editor Despite its widespread use for “skin rejuvenation,” there is a surprising paucity of well-controlled, randomized studies of the use of platelet-rich plasma (PRP) in this setting. The study performed by Alam et al1 is the welcome exception, and they should be praised for the effort. However, we would like to draw attention to 2 issues we think are important to fully understand the study’s conclusions. The authors state that they injected either normal saline or 0.02 mL of PRP per injection site. The sites were approximately 1 cm apart, and injections covered the area of a cheek. They also reported injecting a total of 3 mL of PRP per participant in the study’s treatment arm, which would mean 150 injections per cheek. This number seems too high: an average female cheek accommodates between 80 and 90 injection points if placed 1 cm apart.
Pavlović MD, Loubser MD. Use of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin? JAMA Dermatol. 2019;155(6):755. doi:10.1001/jamadermatol.2019.0357
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