An adult woman presented with an asymptomatic umbilical lesion. Examination revealed a lobulated, firm, erythematous, and eroded nodule arising from the umbilicus, consistent with a Sister Mary Joseph nodule (Figure). Computed tomography revealed several calcified deposits throughout the abdominal mesentery without ovarian lesions and a calcified nodule in the umbilicus. Pathologic analysis of the nodule showed a serous papillary carcinoma, a type of adenocarcinoma with numerous psammoma bodies (lamellated dystrophic calcification). She was presumed to have a primary mesenteric cancer metastatic to her umbilicus and died within a year of this diagnosis.
George S, Haber RM. Sister Mary Joseph Nodule Arising From a Metastatic Serous Papillary Carcinoma. JAMA Dermatol. 2019;155(8):956. doi:10.1001/jamadermatol.2019.0768
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