[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 18.206.177.17. Please contact the publisher to request reinstatement.
Views 1,684
Citations 0
Images in Dermatology
May 29, 2019

Sister Mary Joseph Nodule Arising From a Metastatic Serous Papillary Carcinoma

Author Affiliations
  • 1Dalhousie University Medical School, Halifax, Nova Scotia, Canada
  • 2Division of Dermatology, University of Calgary, Calgary, Alberta, Canada
JAMA Dermatol. 2019;155(8):956. doi:10.1001/jamadermatol.2019.0768

An adult woman presented with an asymptomatic umbilical lesion. Examination revealed a lobulated, firm, erythematous, and eroded nodule arising from the umbilicus, consistent with a Sister Mary Joseph nodule (Figure). Computed tomography revealed several calcified deposits throughout the abdominal mesentery without ovarian lesions and a calcified nodule in the umbilicus. Pathologic analysis of the nodule showed a serous papillary carcinoma, a type of adenocarcinoma with numerous psammoma bodies (lamellated dystrophic calcification). She was presumed to have a primary mesenteric cancer metastatic to her umbilicus and died within a year of this diagnosis.

×