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Images in Dermatology
July 10, 2019

Nonfamilial Multiple Trichoepithelioma

Author Affiliations
  • 1Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil
JAMA Dermatol. 2019;155(9):1070. doi:10.1001/jamadermatol.2019.1650

A woman in her 30s presented with multiple papules and nodules on the face, which first appeared in childhood and were progressive into early adult age. She denied any comorbid conditions or systemic symptoms. There were no reports of similar cases in the family, and her parents were not consanguineous. She had 2 adult children and 1 grandchild without any skin or systemic disorders. Physical examination revealed multiple grouped skin-colored papules with fibroelastic consistency on the face (Figure, A) and external auditory canal, leading to facial disfigurement and hearing loss (Figure, B). She also had isolated lesions on the trunk and upper limbs, some with pigmented globules visible on dermoscopy. Mucous membranes, palms, and soles were spared. Two biopsies were performed, 1 from a skin-colored papule on the face and another from a pigmented papule on the trunk, and confirmed the diagnosis of multiple trichoepitheliomas. Genetic testing was unavailable, and diagnosis of nonfamilial multiple trichoepithelioma was made based on medical history, clinical findings, and histopathologic criteria.