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Research Letter
July 10, 2019

Distinct Histopathologic Patterns of Finger Eruptions in Dermatomyositis Based on Myositis-Specific Autoantibody Profiles

Author Affiliations
  • 1Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
  • 2Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
  • 3Department of Dermatology, Japan Community Healthcare Organization, Chukyo Hospital, Nagoya, Aichi, Japan
  • 4Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan
  • 5Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
  • 6Department of Dermatology, Tokyo Women’s Medical University, Tokyo, Japan
JAMA Dermatol. 2019;155(9):1080-1082. doi:10.1001/jamadermatol.2019.1668

A number of myositis-specific autoantibodies have been identified in patients with dermatomyositis (DM), including anti–aminoacyl-transfer RNA synthetase (ARS), antimelanoma differentiation-associated protein 5 (MDA5), and antitranscriptional intermediary factor 1 (TIF1)γ antibodies, each of which is respectively associated with characteristic cutaneous manifestations.1,2 We analyzed the histologic findings of finger lesions based on these 3 myositis-specific autoantibodies.