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Research Letter
July 31, 2019

Association of the Severity of Alopecia With the Severity of Ichthyosis

Author Affiliations
  • 1Section of Dermatology, Division of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania
  • 2Drexel University College of Medicine, Philadelphia, Pennsylvania
  • 3Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut
  • 4Department of Genetics, Yale University School of Medicine, New Haven, Connecticut
  • 5University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania
JAMA Dermatol. 2019;155(9):1077-1078. doi:10.1001/jamadermatol.2019.1520

Congenital ichthyoses are characterized by abnormal epidermal barrier function. Scarring and nonscarring alopecia has been reported, but the pathogenesis is not well understood.1

Clinically, it is difficult to predict which individuals are likely to experience hair loss and at what severity level.1 The question often arises whether alopecia is extensive among patients with more severe skin disease. The primary aim of our study was to investigate the association between severity of ichthyosis and severity of alopecia. The secondary aim of our study was to characterize the severity of alopecia among patients with ichthyosis by genotype.