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July 31, 2019

Lichen Planus Follicularis Tumidus Associated With PD-1 Blockade

Author Affiliations
  • 1The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York
JAMA Dermatol. 2019;155(10):1197-1198. doi:10.1001/jamadermatol.2019.1676

Immune-related cutaneous adverse events (irAEs) associated with checkpoint blockade agents are well described in the literature, and the lichenoid pattern is a commonly observed histologic subtype of irAEs. Clinically, lesions may resemble classic lichen planus and are typically distributed on the trunk and extremities. Herein, we present a case of lichen planus follicularis tumidus (LPFT), a rare variant of lichen planus, appearing as erythematous cystic papules on the cheeks of a patient receiving adjuvant anti-PD-1 (programmed cell death 1) therapy for melanoma.

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