Granuloma annulare (GA) is a granulomatous necrobiotic dermatosis with a variable disease course and treatment response.1 Apremilast is an orally administered small-molecule drug that inhibits phosphodiesterase 4 (PDE4) and is used in the treatment of various inflammatory dermatoses, including chronic cutaneous sarcoidosis.2 Herein, we describe 4 patients with treatment-refractory generalized GA who responded favorably to apremilast.
Bishnoi A, Raj D, Vinay K, Dogra S. Refractory Generalized Granuloma Annulare Treated With Oral Apremilast. JAMA Dermatol. 2019;155(11):1318–1320. doi:10.1001/jamadermatol.2019.2130
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