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September 11, 2019

Orofacial Granulomatosis Presenting With Acquired Lymphangiectasia

Author Affiliations
  • 1Department of Dermatology, Royal Children’s Hospital, Melbourne, Australia
  • 2Department of Anatomical Pathology, Royal Children’s Hospital, Melbourne, Australia
  • 3Department of Paediatrics, University of Melbourne, Melbourne, Australia
  • 4Department of Dermatology, The Royal Melbourne Hospital, Melbourne, Australia
  • 5Department of Dermatology, Monash Health, Melbourne, Australia
  • 6Murdoch Childrens Research Institute, Melbourne, Australia
JAMA Dermatol. Published online September 11, 2019. doi:10.1001/jamadermatol.2019.2689

Orofacial granulomatosis (OFG) is a term encompassing a group of immunologically mediated, recurrent or persistent, inflammatory granulomatous entities that manifest as soft-tissue enlargement of the lips and orofacial area.1 The precise cause of OFG is not fully understood and literature suggests that allergies, infections, or genetic predisposition may play a role. Studies have hypothesized that OFG is associated with, or may be a subtype of, Crohn disease.2 Management of OFG is challenging owing to its chronicity, aesthetic impact, and poor response to treatment.1,3 Herein, we report a novel surgical treatment for a rare clinical manifestation of OFG.

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