A male patient in his 70s presented an asymptomatic, slightly eroded, translucent nodule on his right nipple (Figure, A). There was a family history of cutaneous melanoma in his 2 sisters, daughter, and nephew and breast cancer in his mother and sister. We completed genetic testing of family members and found no genetic mutations in sera samples to predispose them to melanoma skin cancer or breast cancer. The main genes tested were the breast cancer type 1 susceptibility (BRCA1), breast cancer 2–DNA repair associated (BRCA2), partner and localizer of BRCA2 (PALB2), checkpoint kinase 2 (CHEK2), and tumor protein p53 (TP53) genes. A dermoscopic examination of the patient showed a translucent lesion with arborizing vessels and erosion (Figure, B). A punch biopsy was performed.
Ahangari D, Van Eeckhout P, Tromme I. A Translucent Nodule of the Nipple in an Elderly Male Patient. JAMA Dermatol. 2020;156(3):337–338. doi:10.1001/jamadermatol.2019.4253
Dermatology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.