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JAMA Dermatology Clinicopathological Challenge
January 8, 2020

A Translucent Nodule of the Nipple in an Elderly Male Patient

Author Affiliations
  • 1Department of Dermatology, Saint-Luc University Hospital, Brussels, Belgium
  • 2Department of Pathology, Saint-Luc University Hospital, Brussels, Belgium
JAMA Dermatol. Published online January 8, 2020. doi:10.1001/jamadermatol.2019.4253

A male patient in his 70s presented an asymptomatic, slightly eroded, translucent nodule on his right nipple (Figure, A). There was a family history of cutaneous melanoma in his 2 sisters, daughter, and nephew and breast cancer in his mother and sister. We completed genetic testing of family members and found no genetic mutations in sera samples to predispose them to melanoma skin cancer or breast cancer. The main genes tested were the breast cancer type 1 susceptibility (BRCA1), breast cancer 2–DNA repair associated (BRCA2), partner and localizer of BRCA2 (PALB2), checkpoint kinase 2 (CHEK2), and tumor protein p53 (TP53) genes. A dermoscopic examination of the patient showed a translucent lesion with arborizing vessels and erosion (Figure, B). A punch biopsy was performed.

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