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Comment & Response
January 8, 2020

Creation of a Registry to Address Knowledge Gaps in Hidradenitis Suppurativa and Pregnancy

Author Affiliations
  • 1Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • 2Departments of Dermatology and Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • 3Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles
JAMA Dermatol. Published online January 8, 2020. doi:10.1001/jamadermatol.2019.4162

To the Editor We read with interest the Editorial by Naik and Lowes1 and agree that there is an urgent need to advance knowledge in hidradenitis suppurativa (HS). We wish to highlight a particularly vulnerable but overlooked population with HS: those who are pregnant or seeking to become pregnant.

Even though HS disproportionately affects women of reproductive age, there remain significant knowledge gaps regarding the effect of HS and its management on fertility, pregnancy, and maternal and fetal outcomes. Other chronic inflammatory diseases have been shown to affect pregnancy in important ways, including by increasing rates of preterm birth and pregnancy loss.2 Despite these findings, HS—similarly inflammatory, associated with numerous medical comorbidities, and treated with systemic agents (including biologic therapies)—is underrepresented in the literature.

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