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January 29, 2020

Treatment of Netherton Syndrome With Dupilumab

Author Affiliations
  • 1The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York
JAMA Dermatol. Published online January 29, 2020. doi:10.1001/jamadermatol.2019.4608

Netherton syndrome (NS) is an autosomal recessive disorder characterized by congenital ichthyosis, trichorrhexis invaginata, and severe atopy.1 It presents in the neonatal period, and the ichthyosis develops into serpiginous plaques, bordered by a double-edged scale, termed ichthyosis linearis circumflexa. Hair shaft abnormalities present later in life.1,2 We report a case of NS successfully treated with dupilumab, an interleukin (IL) 4 and IL-13 α antagonist.

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