Over the past 15 years, many new treatments for psoriasis have been developed that achieve better, more rapid, and durable efficacy. The availability of these psoriasis therapies is valuable to both patients and clinicians and offers more options for shared decision making. However, solely relying on the registrational clinical trials that demonstrate the efficacy of these drugs does not allow a full understanding of the relative effect of these medicines weighed against each other. The challenge for the clinician is to go beyond the absolute efficacy of medications to an understanding of their comparative merit and then incorporate this consideration into broader concerns that govern appropriate treatment decisions.
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Strober B, Gordon KB. Comparative Effectiveness Studies for Psoriasis—The Methods Matter. JAMA Dermatol. Published online February 05, 2020. doi:10.1001/jamadermatol.2019.4025
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