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February 5, 2020

Comparative Effectiveness Studies for Psoriasis—The Methods Matter

Author Affiliations
  • 1Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut
  • 2Central Connecticut Dermatology Research, Cromwell
  • 3Medical College of Wisconsin, Milwaukee
JAMA Dermatol. 2020;156(3):253-255. doi:10.1001/jamadermatol.2019.4025

Over the past 15 years, many new treatments for psoriasis have been developed that achieve better, more rapid, and durable efficacy. The availability of these psoriasis therapies is valuable to both patients and clinicians and offers more options for shared decision making. However, solely relying on the registrational clinical trials that demonstrate the efficacy of these drugs does not allow a full understanding of the relative effect of these medicines weighed against each other. The challenge for the clinician is to go beyond the absolute efficacy of medications to an understanding of their comparative merit and then incorporate this consideration into broader concerns that govern appropriate treatment decisions.

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