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March 4, 2020

Complete Remission of Hypertrophic Discoid Cutaneous Lupus Erythematosus After Treatment of Chronic Hepatitis C With Direct-Acting Antivirals

Author Affiliations
  • 1Department of Dermatology, Hospital Clínic de Barcelona, Institut d’Investigació Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain
  • 2Liver Unit, Hospital Clínic de Barcelona, Institut d’Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), University of Barcelona, Barcelona, Spain
JAMA Dermatol. 2020;156(4):471-472. doi:10.1001/jamadermatol.2020.0013

The pathophysiologic features of lupus erythematosus (LE) are complex, and multiple factors have been suggested, such as genetics, drugs, and infections. Although an association of hepatitis C virus (HCV) infection with LE has not been clearly established, a higher proportion of HCV infection among patients with LE has been reported.1,2 In this observation, we report a case of refractory hypertrophic discoid cutaneous LE with complete remission after the treatment of HCV with direct-acting antivirals (DAAs).

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