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Research Letter
April 1, 2020

Mycophenolate Mofetil for Eosinophilic Fasciitis: A Retrospective Analysis From 3 Tertiary Care Centers

Author Affiliations
  • 1University of Massachusetts Medical School, Worcester, Massachusetts
  • 2Department of Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts
  • 3The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York
JAMA Dermatol. 2020;156(5):595-597. doi:10.1001/jamadermatol.2020.0120

Eosinophilic fasciitis (EF) is a fibrosing disorder characterized by edema, erythema, and induration of the extremities. Eosinophilic fasciitis can cause substantial morbidity from joint contractures, and permanent fibrosis may ensue without timely treatment.1 Corticosteroids are considered first-line therapy; however, long-term treatment with corticosteroid-sparing agents is required to avoid sequelae of chronic steroid use and achieve a durable clinical response.2 Although methotrexate is often considered the first-line corticosteroid-sparing agent for EF, there is no standardized treatment ladder.1,3 To our knowledge, 3 cases of EF have reported favorable outcomes with mycophenolate mofetil (MMF) to date.3,4 Given the paucity of data, we investigated the clinical response of EF to MMF in 3 tertiary care centers.

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