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April 15, 2020

Gene Expression Profile Testing for Thin Melanoma: Evidence to Support Clinical Use Remains Thin

Author Affiliations
  • 1Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • 2Department of Internal Medicine, Dell Medical School, The University of Texas at Austin
  • 3LIVESTRONG Cancer Institutes, The University of Texas at Austin
JAMA Dermatol. Published online April 15, 2020. doi:10.1001/jamadermatol.2020.0894

Cutaneous melanoma incidence in the US is increasing, with an estimated 96 480 cases in 2019 compared with 47 700 in 2000 (https://seer.cancer.gov). Most cutaneous melanomas are limited to the skin (84%), defined as stage I or II disease by the American Joint Committee on Cancer.1 For all stages combined, 5-year mortality rate is 7.8%, but mortality is more likely when cutaneous melanoma has metastasized to lymph nodes or organs (stage III or IV).1

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