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May 6, 2020

Association Between High-Grade Myelodysplastic Syndrome and Cutaneous Langerhans Cell Histiocytosis Suggested by Next-Generation Sequencing

Author Affiliations
  • 1Division of Hematology and Medical Oncology, Department of Internal Medicine, Mayo Clinic, Jacksonville, Florida
  • 2Department of Dermatology, Mayo Clinic, Jacksonville, Florida
  • 3Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota
  • 4Department of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, Florida
JAMA Dermatol. Published online May 6, 2020. doi:10.1001/jamadermatol.2020.0544

Langerhans cell histiocytosis (LCH) is a rare dendritic cell disorder with variable cutaneous involvement. Recent evidence suggests that the LCH cell of origin is a myeloid precursor rather than a differentiated epidermal Langerhans cell.1 We report a case of clonally related cutaneous LCH preceded by myelodysplastic syndrome, in which a common clonal origin of these 2 disorders was suggested through next-generation sequencing.

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