Langerhans cell histiocytosis (LCH) is a rare dendritic cell disorder with variable cutaneous involvement. Recent evidence suggests that the LCH cell of origin is a myeloid precursor rather than a differentiated epidermal Langerhans cell.1 We report a case of clonally related cutaneous LCH preceded by myelodysplastic syndrome, in which a common clonal origin of these 2 disorders was suggested through next-generation sequencing.
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Khurana S, Sluzevich JC, He R, et al. Association Between High-grade Myelodysplastic Syndrome and Cutaneous Langerhans Cell Histiocytosis Suggested by Next-Generation Sequencing. JAMA Dermatol. 2020;156(7):817–819. doi:10.1001/jamadermatol.2020.0544
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