Acne affects 85% of adolescents and is the most common skin condition in the United States.1 For many patients, particularly women, acne can also persist into adulthood.2 Acne has substantial psychosocial effect and it is responsible for a greater global burden of disease, as assessed by age-standardized disability-adjusted life years, than psoriasis, cellulitis, and melanoma.3 In the United States, the cost of treatment and lost productivity among those who seek care for acne is more than $1 billion per year.4