Middermal elastolysis (MDE) is a rare skin disease characterized by middermal elastin loss and primarily affects white women between 30 and 50 years of age.1 The etiologic features of MDE are still unknown, but there are striking similarities in the pathogenesis of granuloma annulare (GA) and MDE, which seems to indicate that the etiologic characteristics are related.
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van Delft LCJ, Abdul Hamid M, van Leersum FS. Middermal Elastolysis—A Possible End Stage of Granuloma Annulare. JAMA Dermatol. Published online May 13, 2020. doi:10.1001/jamadermatol.2020.0552
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