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May 13, 2020

Middermal Elastolysis—A Possible End Stage of Granuloma Annulare

Author Affiliations
  • 1Department of Dermatology, Maastricht University Medical Center, Maastricht, the Netherlands
  • 2GROW Research Institute for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands
  • 3Department of Pathology, Maastricht University Medical Center, Maastricht, the Netherlands
JAMA Dermatol. Published online May 13, 2020. doi:10.1001/jamadermatol.2020.0552

Middermal elastolysis (MDE) is a rare skin disease characterized by middermal elastin loss and primarily affects white women between 30 and 50 years of age.1 The etiologic features of MDE are still unknown, but there are striking similarities in the pathogenesis of granuloma annulare (GA) and MDE, which seems to indicate that the etiologic characteristics are related.

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