Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening adverse drug reactions that manifest with full-thickness epidermal necrosis and are often accompanied by fever and other systemic symptoms.1,2 These entities exist on a disease spectrum (herein referred to as SJS-TEN) based on percentage of body surface area with denuded skin.3 Given the rarity of SJS-TEN in the pediatric population, there is no clear, evidence-based therapeutic recommendation beyond discontinuation of the harmful medication and burn-level supportive care.
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Eliades P, Fonseca M, Harp J. Use of Etanercept in a Series of Pediatric Patients With Stevens-Johnson Syndrome–Toxic Epidermal Necrolysis Spectrum Disease. JAMA Dermatol. 2020;156(8):921–922. doi:10.1001/jamadermatol.2019.3731
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