[Skip to Content]
[Skip to Content Landing]
Views 1,292
Citations 0
Editorial
May 27, 2020

Pathogenesis-Based Therapy With Repurposed Biologics for Monogenic Inflammatory Skin Disorders

Author Affiliations
  • 1Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois
JAMA Dermatol. 2020;156(8):839-841. doi:10.1001/jamadermatol.2020.1018

As the underlying basis for common inflammatory disorders, particularly psoriasis and atopic dermatitis, has been unraveled, monoclonal antibodies (biologics) that target the pathogenic immune skewing in these disorders have become available. Tumor necrosis factor (TNF) inhibitors and, more recently, inhibitors of the T helper cell (TH) 17/interleukin 23 (IL-23) pathway have revolutionized the care of individuals with moderate-to-severe psoriasis. More recently, dupilumab, which inhibits the IL-4/IL-13 receptor, became the first TH2 pathway inhibitor for individuals with moderate-to-severe atopic dermatitis.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    ×