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Research Letter
May 20, 2020

Calcinosis Cutis in the Setting of Chronic Skin Graft-Versus-Host Disease

Author Affiliations
  • 1Department of Dermatology, MedStar Washington Hospital Center/Georgetown University Hospital, Washington, DC
  • 2Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland
  • 3Washington University School of Medicine in St Louis, Division of Dermatology, St Louis, Missouri
  • 4Perelman School of Medicine, Department of Dermatology, University of Pennsylvania, Philadelphia
  • 5Perelman School of Medicine, Department Medicine, University of Pennsylvania, Philadelphia
  • 6Editor, JAMA Dermatology
  • 7Division of Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland
  • 8Immune Deficiency Cell Therapy Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland
JAMA Dermatol. Published online May 20, 2020. doi:10.1001/jamadermatol.2020.1157

Calcinosis cutis is a recognized sequela of systemic sclerosis (SS).1 Systemic sclerosis and sclerotic-type chronic skin graft-versus-host disease (ScGVHD) share several clinical and histologic features; however, high-titer antibodies specifically associated with SS are not typically found in ScGVHD, and the fibrotic features in ScGVHD more closely resemble morphea and eosinophilic fasciitis.2 Whereas calcinosis is well described in SS, there are only 2 reports of calcinosis in the setting of chronic graft-versus-host disease (cGVHD), to our knowledge.3,4 We sought to identify patients with cGVHD with calcinosis to explore predisposing factors and clinical features.

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