Calcinosis cutis is a recognized sequela of systemic sclerosis (SS).1 Systemic sclerosis and sclerotic-type chronic skin graft-versus-host disease (ScGVHD) share several clinical and histologic features; however, high-titer antibodies specifically associated with SS are not typically found in ScGVHD, and the fibrotic features in ScGVHD more closely resemble morphea and eosinophilic fasciitis.2 Whereas calcinosis is well described in SS, there are only 2 reports of calcinosis in the setting of chronic graft-versus-host disease (cGVHD), to our knowledge.3,4 We sought to identify patients with cGVHD with calcinosis to explore predisposing factors and clinical features.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Saardi KM, Rosenstein RK, Anadkat MJ, et al. Calcinosis Cutis in the Setting of Chronic Skin Graft-Versus-Host Disease. JAMA Dermatol. Published online May 20, 2020. doi:10.1001/jamadermatol.2020.1157
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: