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May 20, 2020

Bullous and Exanthematous Lesions Associated With Chimeric Antigen Receptor T-Cell Therapy in a Patient With Diffuse Large B-Cell Lymphoma

Author Affiliations
  • 1Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
  • 2Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, Zhejiang, China
  • 3Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China
  • 4Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
  • 5Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  • 6Shanghai YaKe Biotechnology Ltd, Shanghai, China
JAMA Dermatol. Published online May 20, 2020. doi:10.1001/jamadermatol.2020.0636

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized treatment modalities for patients with relapsed/refractory hematologic cancers.1 As CAR-T therapy becomes more widely applied, toxic effects unique to CAR-T treatment are being identified that may potentially affect any organ or system.2 We report a case of a cutaneous toxic reaction after CAR-T therapy.

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