To the Editor We read with interest the recent article by Cheraghlou et al1 comparing overall survival among patients with stage I melanoma receiving Mohs micrographic surgery (MMS) or wide margin excision (WME). Although we agree that these data potentially support the use of MMS in patients with stage I tumors, we point out an erroneous use of the term noninferiority and suggest a significant limitation not mentioned.
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Hopkins ZH, Secrest AM. Clarification Regarding Noninferiority and a Discussion of Model Selection and Treatment Effects in Observational Research. JAMA Dermatol. Published online June 10, 2020. doi:10.1001/jamadermatol.2020.1310
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