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Research Letter
July 15, 2020

Association of Topical Minoxidil With Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Pathogenic Variants

Author Affiliations
  • 1Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
  • 2Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
JAMA Dermatol. Published online July 15, 2020. doi:10.1001/jamadermatol.2020.2195

LIPH pathogenic variants are a major cause of autosomal recessive woolly hair/hypotrichosis (ARWH; OMIM 278150/604379). To our knowledge, there have been no effective treatments for ARWH, although some reports have found topical minoxidil to improve hypotrichosis.1 We report the results of a prospective nonrandomized clinical trial involving 8 Japanese patients with ARWH carrying LIPH pathogenic variants.

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