LIPH pathogenic variants are a major cause of autosomal recessive woolly hair/hypotrichosis (ARWH; OMIM 278150/604379). To our knowledge, there have been no effective treatments for ARWH, although some reports have found topical minoxidil to improve hypotrichosis.1 We report the results of a prospective nonrandomized clinical trial involving 8 Japanese patients with ARWH carrying LIPH pathogenic variants.
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Taki T, Tanahashi K, Takeichi T, et al. Association of Topical Minoxidil With Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Pathogenic Variants. JAMA Dermatol. Published online July 15, 2020. doi:10.1001/jamadermatol.2020.2195
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