Early Features of Progressive Hemifacial Atrophy—Clinical and Imaging Findings

Krystal M. Jones; Jennifer K. Tan; Ahmad I. Alomari; Mary Beth Son; Ruth Ann Vleugels; John B. Mulliken; Marilyn G. Liang

doi:10.1001/jamadermatol.2020.2593

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July 22, 2020

Early Features of Progressive Hemifacial Atrophy—Clinical and Imaging Findings

Krystal M. Jones, MD¹; Jennifer K. Tan, MD^1,2; Ahmad I. Alomari, MD, MSc³; et al Mary Beth Son, MD⁴; Ruth Ann Vleugels, MD, MPH^1,5; John B. Mulliken, MD⁶; Marilyn G. Liang, MD¹

Author Affiliations Article Information

¹Dermatology Program, Division of Immunology, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts
²Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston
³Division of Vascular and Interventional Radiology, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts
⁴Rheumatology Program, Division of Immunology, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts
⁵Department of Dermatology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
⁶Department of Plastic and Oral Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, Massachusetts

JAMA Dermatol. 2020;156(12):1376-1379. doi:10.1001/jamadermatol.2020.2593

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1 Comment for this article

July 22, 2020

Preventing avoidable loss of vision in children with progressive hemifacial atrophy

Peter Shah, BSc MA FRCOphth FRCP Edin | University Hospitals Birmingham NHS Foundation Trust

Jones et al provide an excellent overview of progressive hemifacial atrophy in children. An important clinical point is to look for ophthalmic features that can be associated with progressive loss of vision, that are often asymptomatic in the early stages.

Iris anomalies and asymmetry, such as congenital ectropion uveae, and glaucoma can be detected by a careful ophthalmic examination. Close teamwork between the the dermatology and ophthalmology teams can prevent avoidable, irreversible loss of vision.

CONFLICT OF INTEREST: None Reported

Early Features of Progressive Hemifacial Atrophy—Clinical and Imaging Findings

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