[Skip to Navigation]
August 12, 2020

Topical Calcineurin Inhibitors and Skin Cancer—Another Piece of the Puzzle

Author Affiliations
  • 1Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
  • 2Women’s College Research Institute, Women’s College Hospital, Toronto, Ontario, Canada
  • 3Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
JAMA Dermatol. 2020;156(10):1053-1054. doi:10.1001/jamadermatol.2020.2239

For most people with atopic dermatitis, management of their skin disease includes years of continuous or intermittent use of topical medications. Counseling on that element of chronic disease management is a crucial part of physician visits for patients with atopic dermatitis. Inevitably, discussions about the long-term safety of patients’ treatment plans are included and these discussions are usually based on little long-term evidence. Randomized clinical trials are often underpowered and too short to detect long-term, rare adverse events. Those clinical discussions became more nuanced with the introduction of the topical calcineurin inhibitors (TCIs) tacrolimus in 2000 and pimecrolimus in 2001, and particularly with the addition of a US Food and Drug Administration black box warning in 2006.1 The addition to the prescribing information warned of potential skin cancer and lymphoma risk associated with TCIs based on the known risk of cancer in patients who have undergone transplantation and then received oral calcineurin inhibitors for immunosuppression, as well as on a number of postmarketing reports of cancers developing after use of TCIs.2

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words