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Research Letter
September 2, 2020

Clinical Characteristics of Lupus Erythematosus Panniculitis/Profundus: A Retrospective Review of 61 Patients

Author Affiliations
  • 1The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York
  • 2Ponce Health Sciences University, Ponce, Puerto Rico
  • 3Department of Dermatology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
JAMA Dermatol. Published online September 2, 2020. doi:10.1001/jamadermatol.2020.2797

Lupus erythematosus panniculitis (LEP) is a rare variant of cutaneous lupus erythematosus characterized by tender, often painful, erythematous subcutaneous indurated nodules or plaques on fatty body areas.1,2 Profound lipoatrophy often occurs, potentially leading to severe disfigurement. While LEP is frequently isolated, coexistence with discoid lupus erythematosus (DLE) (termed lupus profundus) or systemic lupus erythematosus (SLE) may occur.1 Diagnosis is often delayed, increasing the risk for sequalae, such as atrophy and calcinosis.3,4

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