Lupus erythematosus panniculitis (LEP) is a rare variant of cutaneous lupus erythematosus characterized by tender, often painful, erythematous subcutaneous indurated nodules or plaques on fatty body areas.1,2 Profound lipoatrophy often occurs, potentially leading to severe disfigurement. While LEP is frequently isolated, coexistence with discoid lupus erythematosus (DLE) (termed lupus profundus) or systemic lupus erythematosus (SLE) may occur.1 Diagnosis is often delayed, increasing the risk for sequalae, such as atrophy and calcinosis.3,4
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Rangel LK, Villa-Ruiz C, Lo K, et al. Clinical Characteristics of Lupus Erythematosus Panniculitis/Profundus: A Retrospective Review of 61 Patients. JAMA Dermatol. Published online September 02, 2020. doi:10.1001/jamadermatol.2020.2797
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: