Epidermal necrolysis (EN), encompassing the spectrum of Stevens-Johnson syndrome and toxic EN, is a rare, severe cutaneous drug reaction with an estimated mortality in modern cohorts of 15% to 23%.1-3 The rarity of the disease makes rigorous prospective clinical research difficult, highlighting the need for multicenter, multinational collaborations as well as iterative efforts to validate and build on prior work.
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Micheletti RG, Noe MH. Improving Outcomes for Patients With Epidermal Necrolysis. JAMA Dermatol. 2020;156(12):1289–1290. doi:10.1001/jamadermatol.2020.3655
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