Granulomatous cheilitis (GC) is a rare disorder characterized by noncaseating granulomatous inflammation of the lips in the absence of systemic disease, eg, Crohn disease (CD) or sarcoidosis.1 A subtype of orofacial granulomatosis, the term GC was proposed in 1985 by Wiesenfeld and colleagues to encompass the spectrum of idiopathic, noncaseating granulomatous diseases of the face and mouth.2 When GC is found with lingua plicata (fissured tongue) and facial palsy, it is referred to as Melkersson-Rosenthal syndrome. Granulomatous cheilitis can have a chronic disfiguring course that is exceedingly difficult to manage.3
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Durgin JS, Rodriguez O, Sollecito T, et al. Diagnosis, Clinical Features, and Management of Patients With Granulomatous Cheilitis. JAMA Dermatol. Published online November 11, 2020. doi:10.1001/jamadermatol.2020.4383
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