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Research Letter
November 11, 2020

Diagnosis, Clinical Features, and Management of Patients With Granulomatous Cheilitis

Author Affiliations
  • 1Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • 2Department of Oral Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • 3Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania
JAMA Dermatol. Published online November 11, 2020. doi:10.1001/jamadermatol.2020.4383

Granulomatous cheilitis (GC) is a rare disorder characterized by noncaseating granulomatous inflammation of the lips in the absence of systemic disease, eg, Crohn disease (CD) or sarcoidosis.1 A subtype of orofacial granulomatosis, the term GC was proposed in 1985 by Wiesenfeld and colleagues to encompass the spectrum of idiopathic, noncaseating granulomatous diseases of the face and mouth.2 When GC is found with lingua plicata (fissured tongue) and facial palsy, it is referred to as Melkersson-Rosenthal syndrome. Granulomatous cheilitis can have a chronic disfiguring course that is exceedingly difficult to manage.3

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