[Skip to Content]
[Skip to Content Landing]
Views 375
Citations 0
Research Letter
November 11, 2020

Diagnosis, Clinical Features, and Management of Patients With Granulomatous Cheilitis

Author Affiliations
  • 1Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • 2Department of Oral Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia
  • 3Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania
JAMA Dermatol. Published online November 11, 2020. doi:10.1001/jamadermatol.2020.4383

Granulomatous cheilitis (GC) is a rare disorder characterized by noncaseating granulomatous inflammation of the lips in the absence of systemic disease, eg, Crohn disease (CD) or sarcoidosis.1 A subtype of orofacial granulomatosis, the term GC was proposed in 1985 by Wiesenfeld and colleagues to encompass the spectrum of idiopathic, noncaseating granulomatous diseases of the face and mouth.2 When GC is found with lingua plicata (fissured tongue) and facial palsy, it is referred to as Melkersson-Rosenthal syndrome. Granulomatous cheilitis can have a chronic disfiguring course that is exceedingly difficult to manage.3

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words
    ×