What is the risk of developing anal carcinoma after anal or genital warts in adults living with HIV?
In this cohort study including 6515 adults living with HIV, 17 of 383 individuals with anogenital warts (4.4%) developed anal carcinoma vs 17 of 6132 individuals without warts of the anogenital region (0.3%). After adjusting for covariates, the odds of developing anal carcinoma were 12.79 times higher in individuals with a history of anogenital warts compared with individuals without a history of anogenital warts.
These findings suggest that persons living with HIV who have anogenital warts should be counseled that they have an increased risk of developing anal carcinoma.
In the US, incidence of and mortality due to anal carcinoma are rising faster than for most other cancers. Identifying populations who have a higher risk of developing anal cancers is critical to target preventive interventions.
To assess the risk of developing anal carcinoma in adults living with HIV who have a history of anogenital warts.
Design, Setting, and Participants
This longitudinal cohort study included adults living with HIV from 14 clinics in Washington, DC, and at least 18 months of follow-up. Data were collected from January 1, 2011, to March 31, 2017, and analyzed from June 1, 2019, to October 31, 2020.
Development of warts in the anal or genital region identified by diagnosis codes.
Main Outcomes and Measures
Individuals with anal carcinoma were identified by diagnosis codes or anal biopsy results.
A total of 6515 participants were enrolled (4720 male [72.4%] at birth; mean [SD] age, 49.9 [12.7] years), and 383 (5.9%) developed anogenital warts during the study period. Patients who were diagnosed with anogenital warts were more likely to subsequently develop anal carcinoma (17 of 383 [4.4%]) compared with participants without a history of anogenital warts (17 of 6132 [0.3%]) (P < .001). After adjusting for covariates, the odds of developing anal carcinoma were 12.79 (95% CI, 6.19-26.45; P < .001) times higher in individuals with a history of anogenital warts compared with individuals without a history of anogenital warts.
Conclusions and Relevance
These findings suggest that adults living with HIV who have a history of anogenital warts have a substantially increased risk of developing anal carcinoma. Clinicians should counsel individuals living with HIV who have anogenital warts on this risk.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Arnold JD, Byrne ME, Monroe AK, Abbott SE, District of Columbia Cohort Executive Committee. The Risk of Anal Carcinoma After Anogenital Warts in Adults Living With HIV. JAMA Dermatol. 2021;157(3):283–289. doi:10.1001/jamadermatol.2020.5252
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: