A 28-year-old African American woman was referred to the dermatology department for a rash that was unresponsive to oral and topical steroids. On examination, the patient had annular erythematous plaques (Figure, A) and corrugated scaling of the flexures (Figure, B). Punch biopsy results of the rash revealed epidermolytic keratosis, and the patient received a diagnosis of annular epidermolytic ichthyosis. Genetic testing was performed, the results of which are pending. The patient was administered methotrexate and cyclosporine with improvement, and was later transitioned to receive ustekinumab, which was followed by disease control.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Foster ML, Jones JM, Schadt CR. Epidermolytic Hyperkeratosis. JAMA Dermatol. Published online July 21, 2021. doi:10.1001/jamadermatol.2021.2325
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: