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February 16, 2022

Ichthyosis Scoring System—A Powerful Tool in the Era of Immune Pathway–Targeted Therapies for Ichthyosis

Author Affiliations
  • 1Department of Dermatology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya, Aichi, Japan
JAMA Dermatol. 2022;158(4):354-356. doi:10.1001/jamadermatol.2021.5342

Inherited ichthyoses are a group of rare genetic keratinization disorders characterized by generalized hyperkeratosis, scaling, and frequently erythema.1 These ichthyoses consist of nonsyndromic ichthyoses and ichthyosis syndromes, and more than 50 types of inherited ichthyoses are known.2 Usually, the skin symptoms of inherited ichthyoses have their onset at birth or in early infancy, and they typically persist for life. Although congenital ichthyoses are a group of rare diseases, most congenital ichthyoses involve severe symptoms in the skin and in various other organs that substantially affect patient quality of life.1,3

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