Livedoid vasculopathy (LV) is a rare vascular disease characterized by erythema, purpura, and painful ulcers with a reticular pattern in the lower extremities, especially on the ankle. Atrophie blanche occurs after the ulcers heal. It manifests as small, stellate, and reticulated white scars. Although the exact cause of LV remains unknown, a hypercoagulable state and endothelial cell damage are likely to be the causative factors. To our knowledge, there is no definitive treatment for LV. However, drugs that stimulate endogenous fibrinolytic activity, anticoagulation, antiplatelet activity, vasodilation, and immunosuppression have shown favorable results in some cases.1 We report 3 cases of LV that were resistant to conventional therapy and showed marked improvement following treatment with baricitinib.
Song X, Tu P. Treatment of Livedoid Vasculopathy With Baricitinib. JAMA Dermatol. 2022;158(5):587–589. doi:10.1001/jamadermatol.2022.0241
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