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Comment & Response
April 27, 2022

Efficacy of Therapies for Actinic Keratosis

Author Affiliations
  • 1Warren Alpert Medical School of Brown University, Providence, Rhode Island
  • 2Departments of Health Services, Policy & Practice and Biostatistics, Brown University, Providence, Rhode Island
  • 3Brown University, Veterans Affairs Medical Center, Providence, Rhode Island
JAMA Dermatol. 2022;158(6):702-703. doi:10.1001/jamadermatol.2022.0889

To the Editor In their network meta-analysis (NMA) of treatments for actinic keratosis (AK), Steeb et al1 concluded that photodynamic therapy with aminolevulinate had the greatest long-term efficacy based on the surrogate outcome of complete clearance of AK at 12 months, followed by imiquimod cream, 5%, photodynamic therapy with methyl aminolevulinate, and cryosurgery. We expand on their concerns regarding clinical relevance of this ranking.

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