To the Editor In their network meta-analysis (NMA) of treatments for actinic keratosis (AK), Steeb et al1 concluded that photodynamic therapy with aminolevulinate had the greatest long-term efficacy based on the surrogate outcome of complete clearance of AK at 12 months, followed by imiquimod cream, 5%, photodynamic therapy with methyl aminolevulinate, and cryosurgery. We expand on their concerns regarding clinical relevance of this ranking.
Lim RK, Trikalinos TA, Weinstock MA. Efficacy of Therapies for Actinic Keratosis. JAMA Dermatol. 2022;158(6):702–703. doi:10.1001/jamadermatol.2022.0889
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