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Images in Dermatology
February 15, 2023

Linear and Annular Lupus Panniculitis of the Scalp

Author Affiliations
  • 1Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
JAMA Dermatol. 2023;159(4):448. doi:10.1001/jamadermatol.2022.5631

A 5-year-old boy presented with a mildly pruritic, arcuate patch of alopecia of 3 years’ duration. The patient and his family reported that the hair loss was initially focal but had enlarged in a linear pattern toward the frontal scalp during the preceding year, with associated erythema on the left forehead (Figure, A). The results of the hair pull test, metabolic profile, complete blood cell count, and autoimmune screening studies (including immunoglobulin levels, erythrocyte sedimentation rate, C3, C4, antinuclear antibody, anti–double-stranded DNA, and anti-Smith, anti-Ro/Sjögren syndrome A, and anti-La/Sjögren syndrome AB antibodies) all proved unremarkable. Skin biopsy specimens obtained from the alopecic patch and erythematous rim revealed dense lymphocytic infiltrates in the deep dermis and hyaline fat necrosis with mild lymphocytic infiltrates in the subcutis (Figure, B). Abundant mucin deposition was highlighted with Alcian blue staining. A diagnosis of linear and annular lupus panniculitis of the scalp (LALPS) was made. Treatment was initiated with oral (prednisolone) and topical corticosteroids, which were continued for 4 weeks with subsequent tapering of prednisolone and continuation of topical therapy only. After 6 months, the erythema had resolved, and nearly complete hair regrowth was observed.

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