Neuropathic pruritus (NP) is characterized by severe itch that is secondary to dysregulation of the somatosensory nervous system. It is often resistant to treatment and associated with a severe reduction in quality of life. To our knowledge, there are currently no approved therapeutics for NP, and patients are often recalcitrant to off-label therapeutics.1 Brachioradial pruritus (BRP) is a subtype of NP that is associated with cervical spinal abnormalities in the C5 to C6 distribution.2 In this article, we report a case of successful use of intravenous ketamine for treating BRP.