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January 2005

Subcutaneous Myeloid Sarcoma

Arch Dermatol. 2005;141(1):104-106. doi:10.1001/archderm.141.1.104

Myeloid sarcomas are extramedullary tumors composed of immature myeloid precursors. We describe a patient with myeloproliferative disorder (MPD) who developed lesions that clinically resembled an inflammatory panniculitis but on histologic analysis were found to be subcutaneous myeloid sarcomas.

A 75-year-old morbidly obese woman presented for evaluation of progressive lethargy, weakness, bone pain, and an 18-kg weight loss. Her white blood cell count was 139 × 109/L, with 16% band cells and 8% blast cells on peripheral smear. A bone marrow biopsy showed hypercellular marrow, an increased myeloid-erythroid ratio, and 4% blast cells. A Philadelphia chromosomal rearrangement was not detected. She was diagnosed was having unclassifiable MPD.1

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