We describe 2 patients whose dermatologic signs of Mali acroangiodermatitis led to the rare diagnosis of homozygous activated protein C resistance (APCR). Since its discovery in 1993, APCR has been found to be the most frequent hereditary coagulation defect. Persons with a heterozygous mutation have an increased risk of thrombosis (up to 10-fold), and the risk is up to 80-fold in persons with homozygous mutations; when thrombosis occurs, it is at a markedly younger age. Three percent of the population is heterozygous for factor V Leiden, and a very low percentage (0.02%) is homozygous.1