Multiple eruptive dermatofibromas (MDFs) are rarely encountered in clinical practice, as opposed to the common solitary dermatofibroma. They can develop suddenly in association with collagen vascular diseases, various autoimmune conditions, human immunodeficiency virus infection, or treatment with steroids. Association with acute myelogenous leukemia was reported in 1 case, and the immunosuppression was thought to be the cause of MDF.1