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July 2005

Pseudoglucagonoma Syndrome in a Patient With Malnutrition

Arch Dermatol. 2005;141(7):914-916. doi:10.1001/archderm.141.7.914

We report a case of pseudoglucagonoma syndrome in a patient with malnutrition. Glucagonoma syndrome is quite a rare disorder, and pseudoglucagonoma syndrome has been described in an even smaller group of patients. Data on incidence, prevalence, and pathogenesis are not currently established for this syndrome.

For several months, a 38-year-old man had a progressive skin eruption. For a few years prior to the eruption, he noticed recurrent episodes of pruritus, diarrhea, angular cheilitis, glossitis, diffuse alopecia, and changes in hair color and nails. One month before presentation, he developed extensive pruritic erythematous patches that became superficial vesicles and bullae. Each individual patch expanded after central crust formation, and the edges progressed to form a well-demarcated circinate pattern (Figure 1). His medical history included a colectomy and pancreaticoduodenojejunostomy after a car crash in 1998. He also had adult-onset diabetes mellitus, osteoporosis, hypoalbuminemia due to malnutrition, anemia, and a 50-lb (22.7-kg) weight loss. He appeared markedly cachectic.

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