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October 2005


Arch Dermatol. 2005;141(10):1317-1318. doi:10.1001/archderm.141.10.1317

Filler substances are highly effective for improving skin textural irregularities associated with facial aging and scarring. Most fillers, such as the nonanimal stabilized hyaluronic acid (NASHA) filler Restylane (Medicis Aesthetics Inc, Scottsdale, Ariz), are supplied in prefilled syringes. In most clinical situations, use of an entire syringe is appropriate, but in some cases only small amounts of filler are needed. When an amount less than the volume provided in a single syringe is used, clinicians may end up discarding the remaining portions, leading to considerable waste and unnecessary cost to the patient. However, some clinicians store the unused material in its prefilled syringe. This practice is based on years of experience with collagen-based filler substances and autologous fat. We conducted a study to determine the sterility of partially used stored syringes of NASHA filler gel.