Ankyloblepharon–ectodermal defect–cleft lip and/or palate (AEC) (Hay-Wells syndrome, Online Mendelian Inheritance in Man No. 106220) belongs to a large, heterogeneous group of ectodermal dysplasias (EDs) that affect embryonic development of ectodermal tissues. The EDs most commonly present with defects in the hair, nails, teeth, sweat glands, and skin. The number and definition of distinct ED syndromes are ambiguous because of overlapping phenotypes and genotypes, and estimates of their overall incidence vary widely; estimates of 1:100 000 births in the United States and 7:10 000 internationally have been reported.1
Siegfried E, Bree A, Fete M, Sybert VP. Skin Erosions and Wound Healing in Ankyloblepharon–Ectodermal Defect–Cleft Lip and/or Palate. Arch Dermatol. 2005;141(12):1591–1594. doi:10.1001/archderm.141.12.1591
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