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December 2005

Infliximab Combined With Methotrexate as Long-term Treatment for Erythrodermic Psoriasis

Arch Dermatol. 2005;141(12):1607-1610. doi:10.1001/archderm.141.12.1607

Severe erythrodermic psoriasis, unresponsive to systemic treatments, is disabling for the patient and a challenge for dermatologists. Methotrexate, cyclosporine, and acitretin have been the treatments of choice.1 However, long-term therapy with these drugs often leads to difficult complications or adverse effects. Thus, new biologic agents such as tumor necrosis factor (TNF) inhibitors provide a welcome alternative. In controlled clinical trials, infliximab has proven to be an effective and fast-acting treatment for plaque-type psoriasis.2-4

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