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Comments and Opinions
March 2006

T-Cell Clonality of Undetermined Significance

Arch Dermatol. 2006;142(3):393-403. doi:10.1001/archderm.142.3.393-c

In a recent article and an accompanying editorial in the ARCHIVES, Gniadecki and Lukowsky1 and Burg et al2 introduced the term T-cell dyscrasia of undetermined significance. The concept of monoclonal T-cell expansion of undetermined significance, however, was already introduced in 19923; it was strengthened in 1994 by the description of a T-cell equivalent of benign monoclonal gammopathy in healthy, elderly humans.4 T-cell clonality of undetermined significance (TCCUS) in different skin conditions was reported by us in 2001.5

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