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April 2006

Annular Elastolytic Giant Cell Granuloma Heralding Onset and Recurrence of Acute Myelogenous Leukemia

Arch Dermatol. 2006;142(4):532-533. doi:10.1001/archderm.142.4.532

Annular elastolytic giant cell granuloma (AEGCG) is an inflammatory eruption characterized clinically by erythematous papules and annular plaques on sun-exposed skin and histologically by granulomatous inflammation accompanied by loss of elastic tissue and elastophagocytosis. We report the case of a man with AEGCG who subsequently developed acute myelogenous leukemia (AML) and in whom the AEGCG behaved in a fashion parallel with his leukemia.

A 57-year-old man presented with a 9-month history of a pruritic eruption on sun-exposed areas of his body that began shortly after a vacation during which he had had significant exposure to sunlight. On examination, the patient had multiple reddish brown erythematous papules coalescing to plaques on his head and neck, chest, upper back, forearms, dorsal hands, and legs (Figure 1). Some papules had an annular arrangement.

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