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June 2006

Disseminated White Papules—Diagnosis

Author Affiliations


Arch Dermatol. 2006;142(6):775-780. doi:10.1001/archderm.142.6.775-g

The biopsy specimen revealed a hypertrophied and hyperplastic epidermis consisting of enlarged keratinocytes that contained multiple large intracytoplasmic eosinophilic inclusion bodies (molluscum bodies). These findings were consistent with a diagnosis of MC. Histopathologic examination of a biopsy specimen from a lichenified plaque on the forearm (not shown) revealed chronic eczematous dermatitis. The patient's laboratory data showed eosinophilia (2.5×103/μL; reference value, <0.3×103/μL) and an elevated IgE level (20 400 IU/mL; reference value, <100 IU/mL). The results of testing for anti–human immunodeficiency virus antibody were negative. Based on the clinical and microscopic findings, the patient was diagnosed as having hyper-IgE syndrome.

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