A 61-year-old man presented with a 3-week history of intractable diarrhea and a 20-lb (9-kg) weight loss. Abdominal computed tomography findings demonstrated a mass in the body of the pancreas and a few hepatic nodules. Results of fine-needle aspiration biopsy of the hepatic lesions revealed clusters of uniform polygonal cells with scant cytoplasm. The cells showed positive reaction to neuron-specific enolase and chromogranin consistent with a metastatic neuroendocrine tumor. Subsequently, the patient underwent irradiation and chemotherapy.
Ram R, Natanzi N, Saadat P, Eliav D, Vadmal MS. Skin Metastasis of Pancreatic Vasoactive Intestinal Polypeptide Tumor: Case Report and Review of the Literature. Arch Dermatol. 2006;142(7):927–947. doi:10.1001/archderm.142.7.946